As a tumor marker, AFP is useful in detecting germ cell tumors of the ovary and testis, primary hepatocellular carcinoma in adults, and hepatoblastoma in children. The hCG hormone plays an important role in your pregnancy, and the changing levels of this hormone in your body are just one of many transformations your body goes through as your baby develops . Lancet 1977; 1:1323–32. 4. Wide variation in maternal serum alpha-fetoprotein reports in one metropolitan area: concerns for the quality of prenatal testing . Elevated levels of alpha-fetoprotein were especially likely to be associated with fetal death in cases in which maternal hypertension or placental infarction was also present. Am J Med Genet 1986; 25:327–33. We are indebted to John Arnopp and Lynn Palmer for technical assistance. Elevated alpha fetoprotein (AFP) in both maternal serum and amniotic fluid and elevated amniotic fluid acetylcholinesterase (AChE) have been correlated with abdominal wall defects when there is no myelomeningocele. Prenat Diagn 1986; 6:369–73. Values. 14. Bakketeig LS, Hoffman HJ, Titmuss Oakley AR. Normal AFP <5.4 ng/ml (5.4 ug/L) AFP >500 ng/ml unlikely to be from benign cause; Nonseminomatous germ cell tumor. I am 16 weeks pregnant, age 30, 127lbs, and my AFP levels from a blood test came at 31 ng/ml. In cases in which the gestational age was found to be inaccurate, the alpha-fetoprotein value was recalculated with the correct gestational age. Second trimester prenatal screening may include several blood tests, called multiple markers. The percentage of fetal deaths associated with maternal alpha-fetoprotein levels at least 2.0 times the median was 12.2 percent (17 of 139) between 20 and 23 weeks of gestation, 15.7 percent (16 of 102) between 24 and 27 weeks, 18.1 percent (15 of 83) between 28 and 31 weeks, 14.5 percent (24 of 166) between 32 and 37 weeks, and 4.9 percent (6 of 122) at 38 weeks or more. However, high levels of AFP can also indicate that the mother is further along in her pregnancy than realized and her due date needs to be recalculated. There were 78 fetal deaths in women with values of 2.0 multiples of the median or higher. The normal level for most healthy adults is between 0 and 8 ng/mL. In this way can get a clear serum. Lammer EJ, Brown LE. . Neural tubes defect varies from small myelomeningocele to anencephaly. At 7 weeks pregnant, your hCG levels can range from about 4,059 to 153,767 mIU/mL. Normal AFI varies from 80 mm to 180mm. Am J Hum Genet 1964; 16:1–25. A high AFP could also mean the mother is carrying twins, according to Kaiser Permanente. Author information: (1)Unidade de Genética Médica, Imunologia, Ginecologia e Obstetrícia, Hospital de Clínicas de Porto Alegre, RS. One of these is the alpha-fetoprotein (AFP) test that can detect any fetal abnormalities around 18 weeks of pregnancy. To the contrary, we found that elevated levels of alpha-fetoprotein were predictive of fetal death in pregnant women with or without vaginal bleeding. AFP is a protein normally made by the immature liver cells in the fetus. Raised levels of maternal AFP at 16-18 weeks of gestation are found in fetal neural tube defects. In other words, her AFP result is 2 times higher than “normal.” So how is the AFP MoM interpreted? Peer-reviewed journal featuring in-depth articles to accelerate the transformation of health care delivery. Serum AFP was measured in 17 071 cases at 11–13 weeks, in 8583 cases at 19–24 weeks and 8609 cases at 30–34 weeks' gestation. 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