Mineral wool can hold a whopping 85-93% of its volume in water, which is the property that increases green roof retention significantly. Synonyms for phenol in Free Thesaurus. Proper training for using phenol and personal protection equipment such as aprons and eye wear is recommended while handling phenol. I was going to talk about spilling phenol red on moccasins and the question was changed before I could answer it. By far, its largest single use is in manufacture of phenolic resins and plastics. The cellular uptake of phenol red was verified using 125I-labeling techniques. See this image and copyright information in PMC. For the aqueous solution, add 0.02 g of phenol red to 75 ml of DI water. The crystals are hygroscopic and turn pink to red in air. American Scientific Publishers; Stevenson Ranch, CA, USA: 2007. pp. Although the CBs were either nontoxic or slightly toxic, as vehicles of phenol red, they played an essential role in the cytotoxicity induced by phenol red. Phenol red is a dye solution and will stain skin and clothing. The Prior Informed Consent Regulation administers the import and export of certain hazardous chemicals and places obligations on companies who wish to export these chemicals to non-EU countries. Phenol red is 3H-2,1-Benzoxathiole 1,1-dioxide in which both of the hydrogens at position 3 have been substituted by 4-hydroxyphenyl groups. It is essential that phenol users understand its properties and know correct handling procedures. Potentially toxic to reproduction: comes from a harmonised C&L classifying the substance as suspected toxic to reproduction Repr. Although the CBs were either nontoxic or slightly toxic, as vehicles of phenol red, they played an essential role in the cytotoxicity induced by phenol red. Phenol has a distinct odor that is sickeningly sweet and tarry. Tests indicate that phenol actually inhibits phagocytic activity. 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Calcium chloride is slightly toxic by ingestion. However, MWNTs showed an intrinsic cytotoxicity independent of phenol red. All data shown are the mean values of three experiments ± SEM. Occupational exposure limit (OEL) values are derived within two legal frameworks that form an integral part of the EU’s mechanism for protecting the health of workers. Dilute to a final volume 100 ml with DI water. Cleveland, OH: Chemical Rubber Co., p. 329. Instead, they react as weak organic acids. It has a burning taste and a distinctive odour. It is toxic by ingestion, and inhalation of its fumes, and skin absorption. The size-dependent cytotoxicity of CBs was found to closely correlate to adsorption of phenol red, cellular uptake of phenol red-CB complexes and the amount of phenol red delivered into the cells by CBs. Ambient levels of phenol are quite low compared to the threshold limit value (TLV) of 5 p.p.m. 2. Lefaux R [1978]. Phenol is used primarily in the production of phenolic resins and in the manufacture of nylon and other synthetic fibers. Deaths have been caused if it is on more than 25% of the skin area or if as little as 15 mL are consumed. Diss Subs Info is temporarily unavailable. Phenol is a highly toxic compound causing protein degradation and tissue erosion. Phenol is considered to be corrosive to the skin and it is known to be a protoplasmic poison: i.e. What are synonyms for phenol? NIH Contact Us. Ding SM, Zhang ZH, Song J, Cheng XD, Jiang J, Jia XB. Other uses include manufacture of explosives, fertilizers, paints, rubber, textiles, adhesives, drugs, paper, soap, wood preservatives, … Nel A., Xia T., Madler L., Li N. Toxic potential of materials at the nanolevel. -. The structure of phenol itself shows its reactivity which lead to its properties like persistence in environment, toxicity and the possibilities of carcinogenic properties toward living organism. Phenols are widely used in household products and … In its pure state, phenol is a toxic and potentially deadly substance. P90 being most toxic. Clipboard, Search History, and several other advanced features are temporarily unavailable. The cellular uptake of phenol red was verified using 125I-labeling techniques. It is a mildly acidic, water-soluble chemical that requires safe handling due its ability to cause chemical burns. 7. It was the first test of kidney function and was used for almost a century but is now obsolete. Wang R, Lee M, Kinghorn K, Hughes T, Chuckaree I, Lohray R, Chow E, Pantano P, Draper R. Nanotoxicology. Welcome to the ECHA website. Human data: It has been stated that the toxicity of phenol is closely related to that of cresol [ACGIH 1991]. Click here for all products containing this ingredient. April 2016 . If safety glasses/goggles and aprons are worn, this material isn't very dangerous. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. https://www.monash.edu/.../safety-topics/chemical-management/phenol On contact with eye and skin, it causes irritation and if inhaled, it is harmful for respiratory tract and digestive system. There is a cumulative effect. Dumortier H., Lacotte S., Pastorin G., Marega R., Wu W., Bonifazi D., Briand J.P., Prato M., Muller S., Bianco A. Functionalized carbon nanotubes are non-cytotoxic and preserve the functionality of primary immune cells. The size-dependent cytotoxicity of CBs was found to closely correlate to adsorption of phenol red, cellular uptake of phenol red-CB complexes and the amount of phenol red delivered into the cells by CBs. Toxic materials are detected in the same manner as in Example 1, except that both phenol red and phenolphthalein are used as pH indicators instead of phenol red alone. Toxic Phenol Ingredient in Vaccines. Toxic properties of phenol … Phenol is both a manufactured chemical and a natural substance. phenol red: ( fē'nol-sŭl'fōn-thal'ē-in, -thal'ēn ), An indicator in tissue culture media (yellow at pH 6.8, red at pH 8.4); occurs as a bright to dark red crystalline powder; in the past given by parenteral injection as a test for renal function. Other Concerns; Functions ; About the Chemical; Synonyms; 4,4'-(3H-2,1-BENZOXATHIOL-3-YLIDENE)BISPHENOL, S,S-DIOXIDE, PHENOL RED, PHENOL, 4,4 (3H2,1BENZOXATHIOL3YLIDENE)BIS, S,SDIOXIDE, and PHENOL, 4,4'-(1,1-DIOXIDO-3H … Among phenolic antioxidant compounds, especially flavonoids offer an intriguing promise, as they are typically both ROS scavenger and metal chelators, potentially offering double protection. Because of its anesthetic effects, phenol is used in medicines such as ointments, ear and nose drops, cold sore lotions, throat lozenges 1991 Dec;129(6):3321-30. doi: 10.1210/endo-129-6-3321. Please upgrade your Internet Explorer to a newer version. Phenol reacts with red blood cells, causing their destruction, preventing the transfer of molecular oxygen to the brain cells. USA.gov. Because of its anesthetic effects, phenol is used in medicines such as ointments, ear and nose drops, cold sore lotions, throat lozenges ... which is toxic, to sulfate. Phenol is soluble in alcohol, glycerol, petroleum, and, to a lesser extent, water. Referring to FIG. Phenol is toxic and the detrimental effects of injected phenol on human health have not been fully evaluated. Hygienic and toxicologic features of products of phenol destruction in ozone treatment of water. Phenol is obtained by fractional distillation of coal tar and by organic synthesis. askEHS; Mission & Values; Organizational Chart Robert van Lith, Guillermo A. Ameer, in Oxidative Stress and Biomaterials, 2016. According to the National Institutes of Health, phenol is toxic and people who are hypersensitive to it could experience death or serious side effects at very low exposures. If advice from a physician is not readily available and the victim is conscious and … This is unique source of information on the chemicals manufactured and imported in Europe. FIGS. It may also be very irritating to skin and eyes. The commercial product is a liquid. Phenol is toxic to bacteria and fungi, and it is used as a slimicide and disinfectant. It covers their hazardous properties, classification and labelling, and information on how to use them safely. 2018 Sep;12(7):677-698. doi: 10.1080/17435390.2018.1472309. Epub 2018 May 26. Mineral wool is an excellent material for increased retention capacity and the resilience of extensive vegetated roofs. Enhanced bioavailability of apigenin via preparation of a carbon nanopowder solid dispersion. IMMEDIATELY call a hospital or poison control center and locate activated charcoal, egg whites, or milk in case the medical advisor recommends administering one of them. Phthalein test: On heating phthalein anhydride with phenol in the presence of concentrated sulfuric acid, phenolphthalein is formed which gives red color with sodium hydroxide. 2014 May;46(2):232-46. doi: 10.3109/03602532.2014.883406. Proper training for using phenol and personal protection equipment such as aprons and eye wear is recommended while handling phenol. 10. Phenol red was used by Leonard Rowntree and John Geraghty in the phenolsulfonphthalein test to estimate the overall blood flow through the kidney in 1911. PLoS One. Phenols do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Drug Metab Rev. Synonym(s): phenol red Plus, it is rapidly absorbed and can cause toxicity throughout the entire body. Phenol was used in hygienic soaps and even as surgical disinfectants, but only for a short period of time because phenol is toxic and can irritate skin. This website uses cookies to ensure you get the best experience on our websites. Endocrinology. Toxic to Reproduction (R) – Recognised as toxic to reproduction: comes from a harmonised C&L classifying the substance as Carc. 1A or 1B and/or an entry in the Candidate list. 4 synonyms for phenol: carbolic acid, hydroxybenzene, oxybenzene, phenylic acid. The CLP Regulation ensures that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union through classification and labelling of chemicals. MagicJigPipe. Environment, Health and Safety. A-Z Topics; Resource Library; Home. Phenol is considered to be corrosive to the skin and it is known to be a protoplasmic poison: i.e. As phenol red is an origin of toxicity, it is reasonable to speculate that the degree of toxicity should be decided by the quantity of phenol red delivered into cells by CBs. It is very hot and may cause burns from contact and also may cause the ignition of combustible materials. Multidisciplinary Digital Publishing Institute (MDPI). This enzyme is very dependent on the mineral molybdenum. The use of phenol in vaccine preparations introduces a poisonous and caustic substance into the body. Cytotoxicity assessment of Hela cells exposed to MWNTs, PG, S160 and P90 (denoted by 1, 2, 3 and 4, respectively) in serum-free medium with or without phenol red. All of these results suggest that phenol red exhibited no toxicity because of its poor cellular penetration, and the cytotoxicity … Hereby the exploration of reasons for size-dependent toxicity observed in this work may be helpful to better understand the toxicological mechanisms. In industry, phenol is used as a starting material to make plastics, explosives such as picric acid, and drugs such as aspirin. Butylated hydroxytoluene (BHT) has a much lower toxicity and is a common antioxidant in foods. Phenol can catch fire. 1 ppm of phenol = 3.85 mg/m3 air, and 1 mg of phenol!m3 air = 0.26 ppm at 20 °C and 101.3 kPa (760 mmHg) 1.2 Physical and Chemical Properties Phenol is a solid at room temperature and normal atmospheric pressure consisting of white crystals that turn pink or red when exposed to air and light. Epub 2014 Feb 10. When the phenols start backing up … 35.6.1 Toxicology of Phenol. Dose-dependent cytotoxicity of phenol red in serum-free medium (, The cytotoxicity of CNPs dispersed in serum-free medium with or without phenol red (. Phenol is also used in the production of synthetic fibers such as nylon and for epoxy resin precursors such as bisphenol-A. J Appl Toxicol. What is the Classification and Labelling Inventory? It is a colorless-to-white solid when pure. Upon skin contact, skin becomes white with a subsequent red blister-like appearance and an accompanying burning sensation. Grady LH, Nonneman DJ, Rottinghaus GE, Welshons WV. Please enable it to take advantage of the complete set of features! 2006;44:1028–1033. ECHA organises consultations to get feedback from all interested parties and to gather the widest possible range of scientific information for the regulatory processes. Tests indicate that phenol actually inhibits phagocytic activity. 2017 Sep;32(7):1561-1570. doi: 10.1007/s10103-017-2279-6. Carbon. Phenol Red is often used to indicate pH levels in various situations. -. PHENOL RED. Nano Lett. Phenol, chemically known as carbolic acid, is a white, volatile crystal solid. Be careful to mix the chemicals in the amounts called for in the procedure. Flavonoids are a class of polyphenol compounds found ubiquitously in food and … Symptoms Of Phenol Sulphur-Transferase (PST) Defect If the sulphation pathway is not functioning well, a person may not be able to process pheno- lic compounds as fast as they consume them. Hurt R.H., Monthioux M., Kane A. Toxicology of carbon nanomaterials: Status, trends, and perspectives on the special issue. A few drops of ferric chloride solution to phenol gives a violet color harmful effects, tar-like odor is... Hu J. Toxicology of carbon nanomaterials: the role of particle size, shape and composition almost completely, should. Is, one that is readily detected at low concentrations ( 0.05 in. 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